• Dr. José Ignacio Borrell Bilbao

Dr. José I. Borrell MRSC, CChem, CSci
Grup de Química Farmacèutica (GQF)
IQS School of Engineering
Universitat Ramon Llull
Via Augusta 390, E-08017 Barcelona, Spain
Tel.:+34 932 672 000/ +34 660 921 791
Fax: +34 939 056 266

email: 
j.i.borrell@iqs.url.edu

Doctor Enginyer Químic (1985, IQS). Llicenciat en Ciències Químiques (1993, URL). Enginyer Químic (1981, IQS)

Professor Catedràtic, 1994-
Cap del Departament de Química Orgànica, 2002-
Director del Grup d'Enginyeria Molecular (GEM), 2005-2017
Coordinador del Grup de Química Farmacèutica (GQF), 2017-
Coordinador del Màster en Química Farmacèutica 2014-

Assignatures

Química Orgànica I (Grau en Química i Grau en Enginyeria Química)

Química Farmacèutica (Grau en Farmàcia)

Química de Procés i Química Farmacèutica (Màster en Química Farmacèutica)

 

Línies de Recerca

  • Disseny, síntesi i avaluació biològica de nous inhibidors de GPCR,  TK i RTK (càncer), VIH (Sida), VHC (Hepatitis C) i Distròfia Miotònica.
  • Disseny de noves metodologies sintètiques per a sistemes heterocíclics basades en microones.

 

Publicacions rellevants

P. Balsas, A. Esteve-Arenys, J. Roldán, L. Jiménez, V. Rodríguez, J. G. Valero, A. Chamorro-Jorganes, R. Puig de la Bellacasa, J. Teixidó, A. Matas-Céspedes, A. Moros, A. Martínez, E. Campo, A. Sáez-Borderías, J. I. Borrell, P. Pérez-Galán, D. Colomer and G. Roué. Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma. Journal of Hematology & Oncology 2017, 80.

Puig de la Bellacasa, Raimon; Gibert, Albert; Planesas, Jesus M.; Ros-Blanco, Laia; Batllori, Xavier; Badia, Roger; Clotet, Bonaventura; Este, Jose; Teixido, Jordi; Borrell, Jose I. Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors. Organic & Biomolecular Chemistry 2016, 14, 1455-1472.

Martin J. Lavecchia, Raimon Puig de la Bellacasa, José I. Borrell, Claudio N. Cavasotto. Investigating molecular dynamics-guided lead optimization of EGFR inhibitors. Bioorganic & Medicinal Chemistry 2016, 24, 768-778.

Marta Camarasa, Raimon Puig de la Bellacasa, Alex L. Gonzalez, Raül Ondoño, Roger Estrada, Sandra Franco, Roger Badia, Jose Esté, Miguel Angel Martínez, Jordi Teixidó, Bonaventura Clotet, José I. Borrell. Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors. European Journal of Medicinal Chemistry 2016, 115, 463-483.

Mourad Chioua, Marta Perez, Oscar M. Bautista-Aguilera, Matilde Yanez, Manuela G. Lopez, Alejandro Romero, Ramon Cacabelos, Raimon Puig de la Bellacasa, Simone Brogi, Stefania Butini, Jose I. Borrell and Jose Marco-Contelles. Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease. Mini-Reviews In Medicinal Chemistry 2015, 15, 648-658.

Jesús M. Planesas, Violeta I. Pérez-Nueno, José I. Borrell, Jordi Teixidó. Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. Journal of Molecular Graphics & Modelling 2015, 60, 1-14.

Raimon Puig de la Bellacasa, Gaël Roué, Patricia Balsas, Patricia Pérez-Galán, Jordi Teixidó, Dolors Colomer, José I. Borrell, 4-Amino-2-Arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-(8H)-ones as BCR kinase inhibitors for B lymphoid malignancies, European Journal of Medicinal Chemistry, 2014, 86, 664-675.

Camarasa, M. and Barnils, C. and Puig De La Bellacasa, R. and Teixidó, J. and Borrell, J.I., A new and practical method for the synthesis of 6-aryl-5,6-dihydropyrido[2, 3-d]pyrimidine-4,7(3H,8H)-diones, Molecular Diversity, 2013, 17,  525-536.

R.Puig de la Bellacasa, N.Karachaliou, R.Estrada-Tejedor, J.Teixidó, C.Costa, J.I. Borrell, ALK and ROS1 as a joint target for the treatment of lung cancer: A review, Transl. Lung Cancer Res., 2013, 2(2), 72-86.

Galve, Inaki; Puig de la Bellacasa, Raimon; Sanchez-Garcia, David; Batllori, Xavier; Teixido, Jordi; Borrell, Jose I., Synthesis of 2-arylamino substituted 5,6-dihydropyrido[2,3-d]pyrimidine-7(8H)-ones from arylguanidines, Molecular Diversity, 2012, 16, 639-649.

Planesas, Jesus M.; Perez-Nueno, Violeta I.; Borrell, Jose I.; Teixido, Jordi, Impact of the CXCR4 structure on docking-based virtual screening of HIV entry inhibidors, Journal of Molecular Graphics & Modelling, 2012, 38, 123-136.

Laia Ros-Blanco, Judit Anido, Ramon Bosser, Jose? Este?, Bonaventura Clotet, Ana Kosoy, Luis Ruíz-A?vila, Jordi Teixido?, Joan Seoane, and Jose? I. Borrell, Noncyclam Tetraamines Inhibit CXC Chemokine Receptor Type 4 and Target Glioma-Initiating Cells, Journal of Medicinal Chemistry, 2012, 55, 7560-7570.

Raimon Puig-de-la-Bellacasa, Laura Giménez, Sofia Pettersson, Rosalia Pascual, Encarna Gonzalo, José A. Esté, Bonaventura Clotet, José I. Borrell, Jordi Teixidó, Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors, European Journal of Medicinal Chemistry, 2012, 54, 159-174.

Planesas, Jesus M.; Claramunt, Rosa M.; Teixido, Jordi; Borrell, Jose I.; Perez-Nueno, Violeta I., Improving VEGFR-2 Docking-Based Screening by Pharmacophore Postfiltering and Similarity Search Postprocessing, Journal Of Chemical Information And Modeling, 2011, 51, 777-787.

Xavier Berzosa, Sofia Pettersson, Jordi Teixidó & José I. Borrell, A diversity-oriented synthesis of 3-(2-amino-1,6-dihydro-6-oxo-pyrimidin-5-yl)propanoic esters, Molecular Diversity, 2011, 15, 595-601.

Francisco Carrión, Sofia H. Pettersson, Jordi Rifá, Joan Farran, Xavier Batllori, José I. Borrell, Jordi Teixidó, A regiospecific synthesis of both positional isomers of 4.6-disubstituted 2-cyanomethylene-1,2-dihydropyridin-3-carbonitriles, Molecular Diversity, 2010, 14, 755-762.

Pettersson, Sofia; Perez-Nueno, Violeta I.; Mena, Maria Pau; Clotet, Bonaventura; Este, Jose A.; Borrell, Jose I.; Teixido, Jordi, Novel Monocyclam Derivatives as HIV Entry Inhibitors: Design, Synthesis, Anti-HIV Evaluation, and Their Interaction with the CXCR4 Co-receptor, ChemMedChem, 2010, 5, 1272-1281.

Xavier Berzosa, Xavier Bellatriu, Jordi Teixidó, and José I. Borrell, An Unusual Michael Addition of 3,3-Dimethoxypropanenitrile to 2-Aryl Acrylates: A Convenient Route to 4-Unsubstituted 5,6-Dihydropyrido[2,3-d]pyrimidines, Journal of Organic Chemistry, 2010, 75, 487-480.

Sánchez-García, D.; Borrell, J.I.; Nonell, S. One-Pot Synthesis of Substituted 2,2'-Bipyrroles. A Straightforward Route to Aryl Porphycenes. Organic Letters, 2009, 11 (1), 77-79.

 

Grups de recerca

Grup de Química Farmacèutica (GQF)