Dr. Raimon Puig de la Bellacasa Cazorla

SUBJECTS

Fundamentals on Chemical and Biological Laboratory (Degrees in Chemistry and Chemical Engineering)
Laboratory 1+2 (Chemistry and Biology) (Degree in Biotechnology)
Chemistry (Degree in Industrial Technologies Engineering)
Advanced Chemistry (Degree in Pharmacy)

RESEARCH lines

• Synthesis and biological evaluation of new heterocyclic structures with inhibitory capability of G Protein-Coupled Receptors (GPCR), Tyrosine Kinases (TK) and Tyrosine Kinase Receptors (RTK) to treat Cancer, HIV (AIDS), HCV (Hepatitis) and Myotonic Dystrophy.
• Development of new synthetic methodologies

RELLEVANT PUBLICATIONS

Y. Liu, R. Puig de la Bellacasa, B. Li, A. B. Cuenca, S.-Y Liu. The Versatile Reaction Chemistry of an Alpha-Boryl Diazo Compound J. Am. Chem. Soc., 2021, 143 (35) 14059.

J. M. Oliveras, R. Puig de la Bellacasa, R. Estrada-Tejedor, J. Teixidó, J. I. Borrell. 1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications. Pharmaceuticals, 2021, 14, 1029.

I. Galve; R. Ondoño; C. de Rocafiguera; R. Puig de la Bellacasa; X. Batllori; C. Puigjaner; M. Font-Bardia; O. Vallcorba; J. Teixidó, J. I. Borrell. A captured room temperature stable Wheland intermediate as a key structure for the orthogonal decoration of 4-amino-pyrido[2,3-d]pyrimidin-7(8H)-ones. Organic & Biomolecular Chemistry, 2020, 18, 9810-9815.

G. Jubete, R. Puig de la Bellacasa, R. Estrada-Tejedor, J. Teixidó, J. I. Borrell. Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications. Molecules, 2019, 24, 4161.

E. Bou-Petit, E. Picas, C. Puigjaner, M. Font-Bardia, N. Ferrer, J. Sempere, R. Puig de la Bellacasa, X. Batllori, J. Teixidó, R. Estrada-Tejedor, S. Ramon y Cajal, J. I. Borrell. An unequivocal synthesis of 2-aryl substituted 3-amino-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-ones. ChemistrySelect, 2017, 2, 3668-3672.

I. Chaib, N. Karachaliou, S. Pilotto, J. Codony Servat, X. Cai, X. Li, A. Drozdowskyj, C. Codony Servat, J. Yang, C. Hu, A. F. Cardona, G. Lopez Vivanco, A. Vergnenegre, J. M. Sanchez, M. Provencio, F. de Marinis, A. Passaro, E. Carcereny, N. Reguart, C. Garcia Campelo, C. Teixidó, I. Sperduti, S. Rodriguez, C. Lazzari, A. Verlicchi, I. de Aguirre, C. Queralt, J. Wei, R. Estrada, R. Puig de la Bellacasa, J. L. Ramirez, K. Jacobsen, H. J. Ditzel, M. C. Santarpia, S. Viteri, M. A. Molina, C. Zhou, P. Cao, P. C. Ma, T. G. Bivona, R. Rosell.Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC. J Natl. Cancer Inst., 2017, 109(9).

P. Balsas, A. Esteve-Arenys, J. Roldán, L. Jiménez, V. Rodríguez, J. G. Valero, A. Chamorro-Jorganes, R. Puig de la Bellacasa, J. Teixidó, A. Matas-Céspedes, A. Moros, A. Martínez, E. Campo, A. Sáez-Borderías, J. I. Borrell, P. Pérez-Galán, D. Colomer, G. Roué. Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma Journal of Hematology & Oncology, 2017, 10:80.

5-Amino-6,7,8,9-Tetrahydrobenzo[b][1,8]Naphthyridin-2-(1H)-one: The first Example of a new Family of HuperTacrines for Alzheimer’s Disease Therapy. A. Balmori, M. Chioua, R. Puig de la Bellacasa, R. Estrada-Tejedor, L. Ismaili, J. Marco-Contelles, J. I. Borrell. Chemistry Select, 2017, 2, 2605-2610.

M. Camarasa, R. Puig de la Bellacasa, A. L. González, R. Ondoño, R. Estrada, S. Franco, R. Badia, J. Esté, M. Á. Martínez, J. Teixidó, B. Clotet, J. I. Borrell. Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors Eur. J. Med. Chem., 2016, 115, 463-483.

M. J. Lavecchia, R. Puig de la Bellacasa, J. I. Borrell, C. N. Cavasotto. Investigating molecular dynamics-guided lead optimization of EGFR inhibitors. Bioorg. Med. Chem., 2016, 24, 768-778.

R. Puig de la Bellacasa, A. Gibert, J. M. Planesas, L. Ros-Blanco, X. Batllori, R. Badía, B. Clotet, J. Esté, J. Teixidó, J. I. Borrell. Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors. Org. Biomol. Chem., 2016, 14, 1455-1472.

M. Chioua, M. Pérez, O. M. Bautista-Aguilera, M. Yañez, M. G. López, A. Romero, R. Cacabelos, R. Puig de la Bellacasa, S. Brogi, S. Butini, J. I. Borrell, J. Marco-Contelles. Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease. Mini-Reviews in Medicinal Chemistry, 2015, 15(8), 648-658.

R. Puig de la Bellacasa, G. Roué, P. Balsas, P. Pérez-Galán, J. Teixidó, D. Colomer, J. I. Borrell. 4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-(8H)-ones as BCR kinase inhibitors for B lymphoid malignancies Eur. J. Med. Chem., 2014, 86, 664-675.

R. Puig de la Bellacasa, N. Karachaliou, R. Estrada-Tejedor, J. Teixidó, C. Costa, J. I. Borrell. ALK and ROS1 as a joint target for the treatment of lung cancer: a review. Translational Lung Cancer Research, 2013, 2(2), 72-86.

M. Camarasa, C. Barnils, R. Puig de la Bellacasa, J. Teixidó, J. I. Borrell. A new and practical method for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine- 4,7(3H,8H)-diones. Mol. Divers., 2013, 17(3), 525-536.

I. Galve, R. Puig de la Bellacasa, D. Sánchez-García, X. Batllori, J. Teixidó, J. I. Borrell. Synthesis of 2-arylamino substituted 5,6-dihydropyrido[2,3-d]pyrimidine-7(8H)-ones from arylguanidines. Mol. Divers., 2012, 16(4), 639-649.

R. Puig-de-la-Bellacasa, L. Giménez, S. Pettersson, R. Pascual, E. Gonzalo, J. A. Esté, B. Clotet, J. I. Borrell, J. Teixidó. Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors. Eur. J. Med. Chem., 2012, 54, 159-174.

S. Pettersson, V. I. Pérez-Nueno, L. Ros-Blanco, R. Puig de la Bellacasa, M. Obdulia Rabal, X. Batllori, B. Clotet, I. Clotet-Codina, M. Armand-Ugón, J. Esté, J. I. Borrell, J. Teixidó. Discovery of Novel Non-Cyclam Polynitrogenated CXCR4 Coreceptors Inhibitors. ChemMedChem., 2008, 3 (10), 1549-1557.

RESEARCH GROUP

Pharmaceutical Chemistry Group (GQF)