• Dr. Roger Estrada Tejedor

Dr. Roger Estrada Tejedor
Molecular Design Department
IQS
Universitat Ramon Llull
Via Augusta 390, E-08017 Barcelona, Spain
Tel.:+34 932 672 000
Fax: +34 939 056 266 

email: 
roger.estrada @iqs.url.edu

Master’s degree in Applied Statistics (2013, UNED). PhD at Ramon Llull University (URL, 2011). Chemical Engineer degree at IQS (IQS, 2006). Degree in Chemistry at Institut Químic de Sarrià (IQS), Ramon Llull University (URL, 2004).

Assistant Professor (2013), Lecturer (AQU,2015), Associate Professor (2020)

 

SubjectS

Mathematics (Degrees in Chemistry and Chemical Engineering). Molecular Design (Master in Pharmaceutical Chemistry and Degree in Pharmacy).
 

Research Lines

  • Computer-aided drug design applied on muscular dystrophies and oncology.
  • Molecular modelling applied on plant biology.
  • Implementation of new algorithms based on artificial intelligence and its application in medicinal chemistry.
 

Representative publications

L. Duart-Castells; N. Nadal-Gratacós; M. Muralter; B. Puster; X. Berzosa; R. Estrada-Tejedor; M. Niello; S. Bhat; D. Pubill; J. Camarasa; H.H. Sitte; E. Escubedo; R. López-Arnau, Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones, Neuropharmacology, 2021, doi: 10.1016/j.neuropharm.2021.108475.

Oliveras, J.M.; Puig de la Bellacasa, R.; Estrada-Tejedor, R.; Teixidó, J.; Borrell, J.I., 1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications, Pharmaceuticals, 2021, doi: 10.3390/ph14101029.

S. Mitra, R. Estrada-Tejedor, D.C. Volke, M.A. Phillips, J. Gershenzon, L.P. Wright, Negative regulation of plastidial isoprenoid pathway by herbivore-induced β-cyclocitral in Arabidopsis thaliana, Proc. Natl. Acad. Sci. U. S. A., 2021, doi: 10.1073/pnas.2008747118.

E. Bou-Petit, A. Plans, N. Rodríguez-Picazo, A. Torres-Coll, C. Puigjaner, M. Font-Bardia, J. Teixidó, S. Ramon y Cajal, R. Estrada-Tejedor, J.I. Borrell, C4-C5 fused pyrazol-3-amines: When the degree of unsaturation and electronic characteristics of the fused ring controls regioselectivity in Ullmann and acylation reactions, Organic & Biomolecular Chemistry, 2020, doi: 10.1039/D0OB00796J.

R. Ondono; Á. Lirio; C. Elvira; E. Álvarez-Marimon; C. Provenzano; B. Cardinali; M. Pérez-Alonso; A. Perálvarez-Marín; J.I. Borrell; G. Falcone; R. Estrada-Tejedor, Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1, Computational And Structural Biotechnology Journal, 2020, doi: 10.1016/j.csbj.2020.11.053.

G. Jubete; R. Puig de la Bellacasa; R. Estrada-Tejedor; J. Teixidó; J.I. Borrell, Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications, Molecules, 2019, doi: 10.3390/molecules24224161.

F. Sabanés Zariquiey; J. V. da Souza; R. Estrada-Tejedor; A. K. Bronowska, If You Cannot Win Them, Join Them: Understanding New Ways to Target STAT3 by Small Molecules, ACS Omega, 2019, doi:  10.1021/acsomega.9b01601.

R. Estrada-Tejedor, GF. Ecker, Predicting drug resistance related to ABC transporters using unsupervised Consensus Self-Organizing Maps, Scientific Reports, 2018, doi: 10.1038/s41598-018-25235-9.

C. Recasens-Zorzo, T. Cardesa-Salzmann, P. Petazzi, L. Ros-Blanco, et al. Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma, Haematologica, 2018, doi: 10.3324/haematol.2017.180505.

L. Sbicca, A. López González,A. Gresika, A. Di Giorgio, J. Teixido Closa, R. Estrada Tejedor, M. Andréola, S. Azoulay, N. Patino, Exploring the impact of the side-chain length on peptide/RNA binding events, Physical Chemistry Chemical Physics, 2017, 19, 18452 - 18460

A. L. González, P. Konieczny, B. Llamusi, E. Delgado-Pinar, J.I. Borrell, J. Teixidó, E. García-España, M. Pérez-Alonso, R. Estrada-Tejedor, R. Artero, In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models, PLOS one, 2017, DOI: 10.1371/journal.pone.0178931

I.Chaib; N.Karachaliou; S.Pilotto; J.Codony Servat; et al. Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC, Journal of the National Cancer Institute, 2017, 109(9), doi: 10.1093/jnci/djx014.

M. Camarasa; R. Puig de la Bellacasa; À.L. González; R. Ondoño; R. Estrada-Tejedor; S. Franco; R. Badia; J. Esté; M.A. Martínez; J. Teixidó; B. Clotet; J.I. Borrell, Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors, European Journal of Medicinal Chemistry, 2016, 115:463-483.

À. L. González; J. Teixidó; J.I. Borrell; R. Estrada-Tejedor, On the applicability of elastic network models for the study of RNA CUG trinucleotide repeat overexpansion, PLoS ONE, 2016, http://dx.doi.org/10.1371/journal.pone.0152049.

 

Research group

Molecular Design Lab. – Pharmaceutical Chemistry Group (GQF)