• Dr. Xevi Biarnés Fontal

Dr. Xevi Biarnés Fontal
Laboratorio de Bioquímica. Unidad de Bioinformática y Modelización Molecular

Chemical Biology and Biotechnology Group (GQBB)
IQS School of Engineering
Universitat Ramon Llull
Via Augusta 390, E-08017 Barcelona, Spain
Tel. +34 93 267 20 00
Fax +34 93 205 62 66


Philosophy doctor (PhD) by the Universitat de Barcelona (2007), Degree in Bioinformatics and Computational Genomics (Universitat Oberta de Catalunya, 2008), Graduate in Chemistry (IQS, 2003). Post-doctorate in Structural Bioinformatics (International School for Advanced Studies – SISSA, 2008-2010).
Associate Professor, 2013 -
Research Assistant, 2010 - 2013



Bioinformatics (Degree in Biotechnology)
Advanced Bioinformatics (Masters in Bioengineering)
Biomolecular Modeling and Simulation (Masters in Bioengineering)
Informatics and Numerical Methods (Degree in Biotechnology)


Research Lines

  • Genomes bioinformatics analysis
  • Structural bioinformatics
  • Macromolecular modeling
  • Rational design of enzymes
  • Atomic level simulation of biological processes


Representatives publications

Updated list of publications and links to abstracts and main texts: https://scholar.google.es/citations?user=Yj6xIHIAAAAJ
Benetti F, Biarnés X, Attanasio F, Giachin G, Rizzarelli E, Legname G. (2014) "Structural determinants in prion protein folding and stability". Journal of Molecular Biology 426, 3796-3810.
Andrés E, Albesa-Jové D, Biarnés X, Moerschbacher BM, Guerin ME, Planas A. (2014) "Structural basis of chitin oligosaccharide deacetylation". Angewandte Chemie International Edition, 53,  6882-6887.
Athanasakis E, Licastro D, Faletra, Fabretto A, Dipresa S, Vozzi D, Morgan A, d'Adamo AP, Pecile V, Biarnés X, Gasparini P. (2014) "Next generation sequencing in nonsyndromic intellectual disability: From a negative molecular karyotype to a possible causative mutation detection". American Journal of Medical Genetics Part A 164, 170-176.
Romero-García J, Francisco C, Biarnés X, Planas A. (2013) Structure-Function Features of a Mycoplasma Glycolipid Synthase Derived from Structural Data Integration, Molecular Simulations, and Mutational Analysis. PloS one 8, e81990.
Baftizadeh F, Pietrucci F, Biarnes X, Laio A. (2013) “Nucleation Process of a Fibril Precursor in the C-Terminal Segment of Amyloid-beta”. Physical Review Letters, 110, 168103.
Biarnes X, Pietrucci F, Marinelli F, Laio A. (2012) “METAGUI. A VMD interface for analyzing metadynamics and molecular dynamics simulations”. Computer Physics Communications, 183, 203-211.
Biarnés X, Ardevol A, Iglesias-Fernández J, Planas A, Rovira C. (2011) "Catalytic itinerary in 1, 3-1, 4-?-glucanase unraveled by QM/MM metadynamics. Charge is not yet fully developed at the oxocarbenium ion-like transition state". Journal of the American Chemical Society 133, 20301-20309.
Biarnés X, Bongarzone S, Vittorio-Vargiu A, Carloni P, Ruggerone P. (2011) “Molecular motions in drug design: the coming age of the metadynamics method”. Journal of Computer-Aided Molecular Design, 25, 395-402.
Biarnés X, Marchiori A, Giorgetti A, Carloni P, Born S, Behrens M, Meyerhof W. (2010) “Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor”. PLoS One, 5, e12394.
Kranjc A, Bongarzone S, Rossetti G, Biarnés X, Legname G, Cavalli A, Bolognesi ML, Roberti M, Carloni P. (2009) “Docking Ligands on Protein Surfaces: The Case Study of Prion Protein”. Journal Of Chemical Theory And Computation, 5, 2565-2573.
Biarnés X, Ardèvol A, Planas A, Rovira C, Laio A, Parrinello M. (2007) “The conformational free energy landscape of beta-D-glucopyranose. Implications for substrate preactivation in beta-glucoside hydrolases”. Journal of the American Chemical Society, 129, 10686-10693.


Research Groups

Chemical Biology and Biotechnology Group (GQBB)