• Dr. Antoni Planas Sauter

Dr. Antoni Planas
Laboratorio de Bioquímica, Departamento de Bioingeniería
Grupo de Química Biológica y Biotecnología (GQBB)
IQS School of Engineering
Universitat Ramon Llull
Via Augusta 390, 08017 Barcelona, Spain
Tel. +34 93 267 20 00
Fax +34 93 205 62 66

email: 
antoni.planas@iqs.url.edu

Doctor Ingeniero Químico (IQS, 1987), Ingeniero Químico por IQS (1982), Licenciado en Ciencias (Bioquímica) (UAB, 1987). Post-doctorado en Bioquímica y Biología Molecular (University of California, Berkeley, 1988-1989), Investigador (Universitat Autònoma de Barcelona, 1990-1992). Profesor en IQS desde 1993. Profesor Visitante: Univ. of California,Berkeley, USA (1992), Universidad de Antioquia, Colombia (1997 y 2006), INSA, Toulouse, Francia (2005), Univ. of Connecticut, USA (2017-18).

Profesor Catedrático (2002- )
Director del Departamento de Bioingeniería (2007- 2018)
Jefe del Laboratorio de Bioquímica (1993-)
Coordinador del Grupo de Química Biológica y Biotecnología (GQBB, 1999-)
Presidente del Grupo Especializado de Hidratos de Carbono, Real Sociedad Española de Química (2021-)
Miembro de la Junta de Gobierno de la Division of Chemistry in Life Sciences, European Chemical Society (EuChemS) (2020-)
Miembro de la Junta de Gobierno de la European Carbohydrate Organization, representate de España (2015-)
Presidente de la European Carbohydrate Organization (2017-2019)
Académico electo de la Real Academia de Ciencias y Artes de Barcelona (2019-)
Emyl Fischer Award 2013 por la European Carbohydrate Organization

 

Bioquímica (Grado en Química),

Metabolismo y Regulación, Ingeniería de Proteínas, Seminarios Interdisciplinares (Grado en Biotecnología)

Synthetic Biology (Master en Bioingeniería)


Ingeniería enzimática en Glicobiología y Biocatálisis. Dianas biomédicas. Estructura-función de proteínas. Ingeniería metabólica.

  • Ingeniería de proteínas y enzimología de glicosidasas, glicosiltransferasas y esterasas de carbohidratos
  • Dianas terapéuticas en enfermedades infeccionas
  • Biocatálisis: rediseño enzimático, evolución dirigida de enzimas
  • Ingeniería genética y metabólica en bacterias, levaduras y microalguas
  • Proteínas amiloides en enfermedades neurodegenerativas

Lista actualizada de publicaciones: https://scholar.google.com/citations?hl=en&user=cW3eqicAAAAJ

Publicaciones recientes:
M. Castejón-Vilatersana, M. Faijes, A. Planas
Transglycosylation activity of engineered Bifidobacterium lacto-N-biosidase mutants at donor subsites for lacto-N-tetraose synthesis
International Journal of Molecular Sciences 22, 3230 (2021). https://doi.org/10.3390/ijms22063230. 

E.Y. Cotrina, L. Miguel Santos, J. Rivas, D. Blasi, J.P. Leite, M.A. Liz, M. A. Busquets, A. Planas, R. Prohens, A. Gimeno, J. Jiménez-Barbero, L. Gales, J. Llop, J. Quintana, I. Cardoso, G. Arsequell
Targeting transthyretin in Alzheimer’s disease: drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer’s disease
European Journal of Medicinal Chemistry 226, 113847 (2021). https://doi.org/10.1016/j.ejmech.2021.113847.

A.R. Pote, S. Pascual, A. Planas, M.W. Peczuh
Indolyl Septanoside Synthesis for In Vivo Screening of Bacterial Septanoside Hydrolases
International Journal of Molecular Sciences 22, 4497 (2021). https://doi.org/10.3390/ijms22094497.

S. Pascual, A Planas
Carbohydrate de-N-acetylases acting on structural polysaccharides and glycoconjugates
Current Opinion in Chemical Biology 61, 9–18 (2021). https://doi.org/10.1016/j.cbpa.2020.09.003.

C. Alsina, E. Sancho-Vaello, A. Aranda-Martínez, M. Faijes, A. Planas
Auxiliary active site mutations enhance the glycosynthase activity of a GH18 chitinase for polymerization of chitooligosaccharides.
Carbohydrate Polymers 252, 117121 (2021) https://doi.org/10.1016/j.carbpol.2020.117121

E.Y. Cotrina, M. Vilà, J. Nieto, G.Arsequell, A. Planas
Preparative Scale Production of Recombinant Human Transthyretin for Biophysical Studies of Protein-Ligand and Protein-Protein Interactions.
International Journal of Molecular Sciences  21, 9640  (2020). https://doi.org/10.3390/ijms21249640.

E.Y. Cotrina, D. Blasi, M. Vilà, A. Planas, C. Abad-Zapatero, N.B. Centeno, J. Quintana, G. Arsequell,
Optimization of Kinetic Stabilizers of Tetrameric Transthyretin: A Prospective Ligand Efficiency guided Approach.
Bioorganic and Medicinal Chemistry 28, 115794 (2020). http://doi.org/10.1016/j.bmc.2020.115794.

J. Chi, M. Cova, M. de las Rivas, A. Medina., R. Junqueira Borges, P. Leivar, A. Planas, I. Usón, R. Hurtado-Guerrero, L. Izquierdo.
Plasmodium falciparum apicomplexan-specific glucosamine-6-phosphate N-acetyltransferase is key for amino sugar metabolism and asexual blood stage development.
mBio 11:e02045-20 (2020) https://doi.org/10.1128/mBio.02045-20.

N. Orive-Milla, T. Demulle, M. de Mey, M. Faijes, A Planas
Metabolic engineering for glycoglycerolipids production in E. coli: tuning phosphatidic acid and UDP-glucose pathways
Metabolic Engineering 61, 106-119 (2020). https://doi.org/10.1016/j.ymben.2020.05.010.

L. Grifoll-Romero, M.A. Sainz-Polo, D. Albesa-Jové, M.E. Guerin, X. Biarnés, A. Planas
Structure-function relationships underlying the dual N-acetylmuramic and N-acetylglucosamine specificities of the peptidoglycan deacetylase PdaC from Bacillus subtilis.
Journal of Biological Chemistry 294, 19066-80 (2019). doi: 10.1074/jbc.RA119.009510.

C. Alsina, M. Faijes, A. Planas
Glycosynthase-type GH18 mutant chitinases at the assisting catalytic residue for polymerization of chitooligosaccharides
Carbohydrate Research 478, 1-9 (2019). Doi:10.1016/j.carres.2019.04.001.

M. Faijes, M. Castejón, C. Val-Cid, A. Planas
Enzymatic and cell factory approaches to the production of human milk oligosaccharides
Biotechnology Advances 37, 667–697 (2019). https://doi.org/10.1016/j.biotechadv.2019.03.014.

J. Romero-García, X. Biarnés, A. Planas
Essential mycoplasma glycolipid synthase adheres to the cell membrane by means of an amphipathic helix.
Scientific Reports 9, 7085 (2019). http://doi.org/10.1038/s41598-019-42970-9

S. Pascual, A. Planas
Screening assay for directed evolution of chitin deacetylases. application to Vibrio cholerae deacetylase mutant libraries for engineered specificity
Analytical Chemistry 90, 10654–10658 (2018). http://dx.doi.org/10.1021/acs.analchem.8b02729.

C Alsina, A. Aranda-Martínez, E. Sancho-Vaello, X. Biarnés, M. Faijes, A. Planas
Engineering GH18 chitinases for the production of sequence-defined chitosan polymers
Revista de la Societat Catalana de Química 17, 32-44 (2018).

L. Grifoll, S. Pascual, H. Aragunde, X. Biarnés, A. Planas
Chitin deacetylases: structures, specificities, and biotech applications
Polymers 10, 352 (2018). https://doi.org/10.3390/polym10040352.

H. Aragunde, X.Biarnés, A.Planas
Substrate recognition and specificity of chitin deacetylases and related family 4 carbohydrate esterases
International Journal of Molecular Sciences 19, 412 (2018). https://doi.org/10.3390/ijms19020412.

A. Aranda-Martinez, L. Grifoll-Romero, H.Aragunde, E. Sancho-Vaello, X. Biarnés, L. Vicente Lopez-Llorca, A. Planas
Expression and specificity of a chitin deacetylase from the nematophagous fungus Pochonia chlamydosporia potentially involved in pathogenicity
Scientific Reports 8, 2170 (2018). https://doi.org/10.1038/s41598-018-19902-0.

J. Coines, M. Alfonso-Prieto, X. Biarnés, A. Planas, C. Rovira
Oxazoline or oxazolinium ion? The protonation state and conformation of the reaction intermediate of chitinase enzymes revisited
Chemistry A European Journal 24, 19258-19265 (2018). doi: http://dx.doi.org/10.1002/chem.201803905.


Grupo de Química Biológica y Biotecnología (GQBB)