• Dr. Jordi Duran

Dr. Jordi Duran
Departmento de Bioingenieria
IQS School of Engineering
Universitat Ramon Llull
Via Augusta 390, E-08017 Barcelona, Spain
Tel. +34 93 267 20 00
Fax +34 93 205 62 66
 

email: 
jordi.duran@iqs.url.edu

Licenciado en Farmacia (Universitat de Barcelona, 1999)
Licenciado en Bioquímica (Universitat de Barcelona, 2002)
Doctor en Biomedicina (IRB Barcelona, 2007)
Investigador Postdoctoral (IRB Barcelona, 2008-2012)
Investigador Asociado (IRB Barcelona, 2012-2021)

Profesor Asociado (IQS, 2021 - )
Investigador Asociado (IBEC, 2021 - )
 

Asignaturas

Fisiología Molecular (Grado de Biotecnología)
Animales Transgénicos y Terapia Génica (Grado de Biotecnología)

 

Líneas de Investigación

  • Mecanismos patológicos de la enfermedad de Lafora
  • Papel de la acumulación excesiva de glucógeno en enfermedades neurodegenerativas
  • El metabolismo energético en el funcionamiento del sistema nervioso
  • Papeles no-canónicos del metabolismo del glucógeno

 

Publicaciones relevantes

ResearcherID: J-7298-2017
ORCID: 0000-0002-8342-4882
Scopus: 24173344900

Listado completo:


https://scholar.google.com/citations?user=Xb_0-kgAAAAJ&hl
https://www.ncbi.nlm.nih.gov/myncbi/jordi.duran.1/bibliography/public/

Duran J*, Hervera A, Markussen KH, Varea O, López-Soldado I, Sun RC, Del Río JA, Gentry MS, Guinovart JJ. Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease. Brain. 2021 Sep 4;144(8):2349-2360. *autor de correspondencia
https://pubmed.ncbi.nlm.nih.gov/33822008/

Varea O, Duran J*, Aguilera M, Prats N, Guinovart JJ*. Suppression of glycogen synthesis as a treatment for Lafora disease: Establishing the window of opportunity. Neurobiol Dis. 2021 Jan;147:105173. *autores de correspondencia
https://pubmed.ncbi.nlm.nih.gov/33171226/

López-Soldado I, Guinovart JJ, Duran J. Increased liver glycogen levels enhance exercise capacity in mice. J Biol Chem. 2021 Aug;297(2):100976.
https://pubmed.ncbi.nlm.nih.gov/34284060/

López-Soldado I, Guinovart JJ, Duran J. Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice. J Biol Chem. 2021 Jan-Jun;296:100498.
https://pubmed.ncbi.nlm.nih.gov/33667544/

Testoni G, Olmeda B, Duran J, López-Rodríguez E, Aguilera M, Hernández-Álvarez MI, Prats N, Pérez-Gil J, Guinovart JJ. Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome. Hum Mol Genet. 2021 Jan 6;29(21):3554-3565.
https://pubmed.ncbi.nlm.nih.gov/33219378/

Duran J, Brewer MK, Hervera A, Gruart A, Del Rio JA, Delgado-García JM, Guinovart JJ. Lack of Astrocytic Glycogen Alters Synaptic Plasticity but Not Seizure Susceptibility. Mol Neurobiol. 2020 Nov;57(11):4657-4666.
https://pubmed.ncbi.nlm.nih.gov/32770452/

Zuend M, Saab AS, Wyss MT, Ferrari KD, Hösli L, Looser ZJ, Stobart JL, Duran J, Guinovart JJ, Barros LF, Weber B. Arousal-induced cortical activity triggers lactate release from astrocytes. Nat Metab. 2020 Feb;2(2):179-191.
https://pubmed.ncbi.nlm.nih.gov/32694692/

Duran J, Gruart A, López-Ramos JC, Delgado-García JM, Guinovart JJ. Glycogen in Astrocytes and Neurons: Physiological and Pathological Aspects.
Adv Neurobiol. 2019;23:311-329.
https://pubmed.ncbi.nlm.nih.gov/31667813/

Duran J, Gruart A, Varea O, López-Soldado I, Delgado-García JM, Guinovart JJ. Lack of Neuronal Glycogen Impairs Memory Formation and Learning-Dependent Synaptic Plasticity in Mice. Front Cell Neurosci. 2019 Aug 13;13:374.
https://pubmed.ncbi.nlm.nih.gov/31456667/

Augé E, Pelegrí C, Manich G, Cabezón I, Guinovart JJ, Duran J*, Vilaplana J*. Astrocytes and neurons produce distinct types of polyglucosan bodies in Lafora disease. Glia. 2018 Oct;66(10):2094-2107. *autores de correspondencia
https://pubmed.ncbi.nlm.nih.gov/30152044/

Testoni G, Duran J, García-Rocha M, Vilaplana F, Serrano AL, Sebastián D, López-Soldado I, Sullivan MA, Slebe F, Vilaseca M, Muñoz-Cánoves P, Guinovart JJ. Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment. Cell Metab. 2017 Jul 5;26(1):256-266.e4
https://pubmed.ncbi.nlm.nih.gov/28683291/

Duran J, Guinovart JJ. Brain glycogen in health and disease. Mol Aspects Med. 2015 Dec;46:70-7.
https://pubmed.ncbi.nlm.nih.gov/26344371/

López-Ramos JC, Duran J, Gruart A, Guinovart JJ, Delgado-García JM. Role of brain glycogen in the response to hypoxia and in susceptibility to epilepsy.
Front Cell Neurosci. 2015 Oct 27;9:431.
https://pubmed.ncbi.nlm.nih.gov/26578889/

Duran J, Gruart A, García-Rocha M, Delgado-García JM, Guinovart J.  Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease. Hum Mol Genet. 2014 Jun 15;23(12):3147-56.
https://pubmed.ncbi.nlm.nih.gov/24452334/

Saez I, Duran J, Sinadinos C, Beltran A, Yanes O, Tevy MF, Martínez-Pons C, Milán M, Guinovart JJ. Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia. J Cereb Blood Flow Metab. 2014 Jun;34(6):945-55.
https://pubmed.ncbi.nlm.nih.gov/24569689/

Duran J, Saez I, Gruart A, Guinovart JJ, Delgado-García JM. Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain. J Cereb Blood Flow Metab. 2013 Apr;33(4):550-6.
https://pubmed.ncbi.nlm.nih.gov/23281428/

Duran J, Tevy MF, Garcia-Rocha M, Calbó J, Milán M, Guinovart JJ. Deleterious effects of neuronal accumulation of glycogen in flies and mice. EMBO Mol Med. 2012 Aug;4(8):719-29.
https://pubmed.ncbi.nlm.nih.gov/22549942/