Dr. Jordi Teixidó Closa


Dr. Jordi Teixidó i Closa
Grupo de Ingeniería Molecular (GEM)
IQS School of Engineering
Universitat Ramon Llull
Via Augusta 390, E-08017
Barcelona, Spain
Tel.:+34 932 672 000
Fax: +34 939 056 266

email: 
jordi.teixido@iqs.url.edu

Doctor Ingeniero Químico (1991, IQS). Licenciado en Ciencias Químicas (1993, URL). Ingeniero Químico (1987, IQS)
Research Fellow, Rohm & Haas Agrochem. Div, USA (1998)
Profesor Catedrático, 2005-
Responsable del Laboratorio de Diseño Molecular
Secretario General 2012 - 2014
Decano de IQS School of Engineering 2014 -

Asignaturas

Profesor de Matemáticas (Álgebra Lineal), Determinación Estructural, Diseño Molecular, Química General y Química Farmacéutica

 

Líneas de Investigación

  • Diseño Molecular: Química Computacional y métodos Quimiométricos aplicados al diseño y síntesis de nuevas moléculas.
  • Diseño y síntesis de nuevos inhibidores de GPCR, TK y RTK,  VIH (Sida) y VHC (Hepatitis C).
     

 

Publicaciones relevantes

  • Àlex L. González; Jordi Teixidó; José I. Borrell; Roger Estrada-Tejedor, On the applicability of Elastic Network Models for the study of RNA CUG trinucleotide repeat overexpansion. PLoS One, 2016, http://dx.doi.org/10.1371/journal.pone.0152049
  • Marta Camarasa, Raimon Puig de la Bellacasa, Alex L. Gonzalez, Raül Ondoño, Roger Estrada, Sandra Franco, Roger Badia, Jose Esté, Miguel Angel Martínez, Jordi Teixidó, Bonaventura Clotet, José I. Borrell, Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibidors. European Journal of Medicinal  Chemistry, 2016, 115, 463-483.
  • Puig de la Bellacasa, Raimon; Gibert, Albert; Planesas, Jesus M.; Ros-Blanco, Laia; Batllori, Xavier; Badia, Roger; Clotet, Bonaventura; Este, Jose; Teixido, Jordi; Borrell, Jose  I., Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors, Organic & Biomolecular  Chemistry, 2016, 14, #4, 1455-1472.         
  • Lise Pascalea; Alejandro López González; Audrey Di Giorgioa; Marc Gaysinskia; Jordi Teixido Closa; Roger Estrada Tejedor; Stéphane Azoulay; Nadia  Patino, Deciphering structure¬activity relationships in a series of Tat/TAR inhibidors. Journal of Biomolecular Structure &  Dynamics, 2015, 2, 1-54.            
  • Jesús M. Planesas, Violeta I. Pérez-Nueno, José I. Borrell, Jordi Teixidó,Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. Journal of Molecular Graphics &  Modelling, 2015, 60, 1-14
  • Raimon Puig de la Bellacasa, Gaël Roué, Patricia Balsas, Patricia Pérez-Galán, Jordi Teixidó, Dolors Colomer, José I. Borrell, 4-Amino-2-Arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-(8H)-ones as BCR kinase inhibitors for B lymphoid malignancies, European Journal of Medicinal Chemistry, 2014, 86, 664-675.
  • Llinàs, M. C.; Farran, J.; Capparelli, M.V.; Anguera, G.; Sánchez-García, D.; Teixidó, J.; Borrós S., Synthesis and Anion Binding Studies of a new Crown Ether containing 2,2´-biimidazole, Tetrahedron Letters, 2014, 55, 4667-4670.
  • Arnaud S. Karaboga, Jesús M. Planesas, Florent Petronin, Jordi Teixidó, Michel Souchet, Violeta I. Pérez-Nueno, Highly SpecIfic and Sensitive Pharmacophore Model for Identifying CXCR4 Antagonists. Comparison with Docking and Shape-Matching Virtual Screening Performance, Journal Of Chemical Information And Modeling, 2013, 53, 1043-1056.
  • Camarasa, M. and Barnils, C. and Puig De La Bellacasa, R. and Teixidó, J. and Borrell, J.I., A new and practical method for the synthesis of 6-aryl-5,6-dihydropyrido[2, 3-d]pyrimidine-4,7(3H,8H)-diones, Molecular Diversity, 2013, 17,  525-536.
  • R.Puig de la Bellacasa, N.Karachaliou, R.Estrada-Tejedor, J.Teixidó, C.Costa, J.I. Borrell, ALK and ROS1 as a joint target for the treatment of lung cancer: A review, Transl. Lung Cancer Res., 2013, 2(2), 72-86.
  • E.Cirera-Domènech, R.Estrada-Tejedor, F.Broto-Puig, J.Teixidó, M.Gassiot-Matas, Ll.Comellas, J.L.Lliberia, A.Méndez, S.Paz-Estivill, M.R.Delgado-Ortiz, Quantitative structure-retention relationships applied to liquid chromatography gradient elution method for the determination of carbonyl-2,4-dinitrophenylhydrazone compounds, J.Chromatography A, 2013, 1276, 65-77.
  • R.Tejedor-Estrada, S.Nonell, J.Teixidó, M.Ll.Sagristá, M.Mora, A.Villanueva, M.Cañete, J.C.Stockert, An artificial neural network model for predicting the subcellular localization of photosensitisers for photodynamic therapy of solid tumors, Curr. Med. Chem. 2012, 19, 2472-2482.
  • Galve,Inaki; Puig de la,Bellacasa Raimon; Sanchez-Garcia,David; Batllori,Xavier; Teixido,Jordi; Borrell,Jose I., Synthesis of 2-arylamino substituted 5,6-dihydropyrido[2,3-d]pyrimidine-7(8H)-ones from arylguanidines, Molecular Diversity, 2012, 16, 639-649.
  • Planesas,Jesus M.; Perez-Nueno,Violeta I.; Borrell,Jose I.; Teixido,Jordi, Impact of the CXCR4 structure on docking-based virtual screening of HIV entry inhibidors, Journal of Molecular Graphics & Modelling, 2012, 38, 123-136.
  • Laia Ros-Blanco, Judit Anido, Ramon Bosser, Jose? Este?, Bonaventura Clotet, Ana Kosoy, Luis Ruíz-A?vila, Jordi Teixido?, Joan Seoane, and Jose? I. Borrell, Noncyclam Tetraamines Inhibit CXC Chemokine Receptor Type 4 and Target Glioma-Initiating Cells, Journal of Medicinal Chemistry, 2012, 55, 7560-7570.
  • Raimon Puig-de-la-Bellacasa, Laura Giménez, Sofia Pettersson, Rosalia Pascual, Encarna Gonzalo,José A. Esté, Bonaventura Clotet, José I. Borrell, Jordi Teixidó, Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibidors, European Journal of Medicinal Chemistry, 2012, 54, 159-174.
  • Planesas,Jesus M.; Claramunt,Rosa M.; Teixido,Jordi; Borrell,Jose I.; Perez-Nueno,Violeta I., Improving VEGFR-2 Docking-Based Screening by Pharmacophore Postfiltering and Similarity Search Postprocessing, Journal Of Chemical Information And Modeling, 2011, 51, 777-787.
  • Xavier Berzosa, Sofia Pettersson, Jordi Teixidó & José I. Borrell, A diversity-oriented synthesis of 3-(2-amino-1,6-dihydro-6-oxo-pyrimidin-5-yl)propanoic esters, Molecular Diversity, 2011, 15, 595-601.
  • Francisco Carrión, Sofia H. Pettersson, Jordi Rifá, Joan Farran, Xavier Batllori, José I. Borrell, Jordi Teixidó, A regiospecific synthesis of both positional isomers of 4.6-disubstituted 2-cyanomethylene-1,2-dihydropyridin-3-carbonitriles, Molecular Diversity, 2010, 14, 755-762.
  • Pettersson,Sofia; Perez-Nueno,Violeta I.; Mena,Maria Pau; Clotet,Bonaventura; Este,Jose A.; Borrell,Jose I.; Teixido,Jordi, Novel Monocyclam Derivatives as HIV Entry Inhibitors: Design, Synthesis, Anti-HIV Evaluation, and Their Interaction with the CXCR4 Co-receptor, ChemMedChem, 2010, 5, 1272-1281.
  • Gallardo, A; Teixidó, J.; Miralles, R.; Raga, M.; Guglietta, A.; Marquillas, F.; Sallarès, J.; Nonell, S., Dose-dependent progressive sunscreens. A new strategy for photoprotection?, Photochemical & Photobiological Sciences, 2010, 9, 530-534.
  • A.C.Balfagón, A.Serrano-Hernanz, J.Teixidó, R.Tejedor-Estrada, Comparative study of neural networks and least mean square algorithm applied to the optimization of cosmetic formulations, International Journal of Cosmetic Science, 2010, 32(5), 376-386.
  • Xavier Berzosa, Xavier Bellatriu, Jordi Teixidó, and José I. Borrell, An Unusual Michael Addition of 3,3-Dimethoxypropanenitrile to 2-Aryl Acrylates: A Convenient Route to 4-Unsubstituted 5,6-Dihydropyrido[2,3-d]pyrimidines, Journal of Organic Chemistry, 2010, 75, 487-480

 

Grupos de investigación

Grupo de Ingeniería Molecular (GEM)