• Dra. Cristina Fornaguera i Puigvert

Dra. Cristina Fornaguera i Puigvert
Grupo de Ingeniería de Materiales (Gemat)
IQS School of Engineering
Universidad Ramon Llull
Via Augusta 390, E-08017
Barcelona, Spain
Tel.:+34 932 672 000
Fax: +34 939 056 266

email: 
cristina.fornaguera@iqs.url.edu

Doctora en Farmacia (2015, UB). Master en Medicina Respiratoria (UB/UPF). Licenciada en Biotecnología (2010, UAB).
Investigadora visitante, i3S, Porto, Portugal (2021).

Profesora Contratada Doctora 2018-
Coordinadora del Grado en Ciencies Biomédicas 2022-

 

Profesora de Laboratorio Integrado de Biotecnología, Inmunología, Ciencias Biomédicas y Biomateriales, Sistemas Avanzados de Liberación de Fármacos, Nuevas Terapias Biológicas y Workshop en Salud Humana.

 

  • Nanosistemas avanzados de liberación controlada de fármacos y material genético.
  • Diseño de nuevos biomateriales para aplicaciones terapéuticas de enfermedades humanas.
  • Vacunas de mRNA para inmunoterapia del cáncer.
  • Ingeniería de vesículas extracelulares para aplicaciones terapéuticas.

 

Fornaguera C., Grijalvo S., Galán M., Fuentes-Paniagua E., de la Mata F.J., Gómez R., Eritja R., Calderó G., Solans C., NOVEL NON-VIRAL GENE DELIVERY SYSTEMS COMPOSED OF CARBOSILANE DENDRON FUNCTIONALIZED NANOPARTICLES PREPARED FROM NANO-EMULSIONS AS NON-VIRAL CARRIERS FOR ANTISENSE OLIGONUCLEOTIDES. International Journal of Pharmaceutics 478(1) (2015) 113–123. DOI: 10.1016/j.ijpharm.2014.11.031

Fornaguera C.*, Calderó G., Mitjans M., Vinardell P., Solans C., Vauthier C., INTERACTION OF PLGA NANOPARTICLES WITH BLOOD COMPONENTS: PROTEIN ADSORPTION, COAGULATION, ACTIVATION OF THE COMPLEMENT SYSTEM AND HEMOLYSIS STUDIES. Nanoscale, 7 (2015), 6045–6058. DOI: 10.1039/C5NR00733J

Fornaguera C.*, Dols-Pérez A., Calderó G., García-Celma M.J., Camarasa J., Solans C., PLGA NANOPARTICLES PREPARED BY NANO-EMULSION TEMPLATING USING LOW-ENERGY METHODS AS EFFICIENT NANOCARRIERS THROUGH THE BLOOD-BRAIN BARRIER. Journal of Controlled release,211 (2015), 134 – 143. DOI: 10.1016/j.jconrel.2015.06.002.

Fornaguera C.*, Feiner-Gracia N., Calderó G., Garcia-Celma M.J., Solans C., GALANTAMINE-LOADED PLGA NANOPARTICLES, FROM NANO-EMULSION TEMPLATING, AS NOVEL ADVANCED DRUG DELIVERY SYSTEMS TO TREAT NEURODEGENERATIVE DISEASES. Nanoscale, 7 (2015), 12076 – 12084. DOI: 10.1039/C5NR03474D

Fornaguera C., Lázaro M.A., Brugada P., Porcar I., Morera I., Guerra-Rebollo M., Garrido C., Rubió N., Blanco J., Cascante A., Borrós S., APPLICATION OF AN ASSAY CASCADE METHODOLOGY FOR A DEEP PRECLINICAL CHARACTERIZATION OF POLYMERIC NANOPARTICLES AS A TREATMENT FOR GLIOMAS. Drug Delivery 25(1) (2018) 472 – 483. DOI: 10.1080/10717544.2018.1436099

Fornaguera C., Guerra-Rebollo M., Lázaro M.A., Castells-Sala C., Ramos V., Cascante A., Rubió N., Blanco J., Borrós S., mRNA DELIVERY SYSTEM FOR TARGETING ANTIGEN-PRESENTING CELLS IN VIVO. Advanced Healthcare Materials 7(17) (2018) 1800335. DOI: 10.1002/adhm.201800335

Feiner-Gracia N., Dols-Pérez A., Royo M., Solans C., García-Celma M.J., Fornaguera C.*, CELL PENETRATING PEPTIDE GRAFTING OF PLGA NANOPARTICLES TO ENHANCE CELL UPTAKE. European Polymer Journal, 108 (2018) 429 - 438. DOI: 10.1016/j.eurpolymj.2018.09.026.

Balcells L., Fornaguera C., Brugada-Vilà P., Guerra-Rebollo M., Meca-Cortés O., Martínez G., Rubio N., Blanco J., Santamaría J., Cascante C., Borrós S., SPIONS’ ENHANCER EFFECT ON CELL TRANSFECTION: AN UNEXPECTED ADVANTAGE FOR AN IMPROVED GENE DELIVERY SYSTEM. ACS Omega, 4 (2), (2019) 2728–2740. DOI: 10.1021/acsomega.8b02905.

Fornaguera C., Castells-Sala C., Lázaro M.A., Cascante A., Borrós S., DEVELOPMENT OF AN OPTIMIZED FREEZE-DRYING PROTOCOL FOR OM-PBAE POLYPLEXES. International Journal of Pharmaceutics 569 (2019) 118612. DOI: 10.1016/j.ijpharm.2019.118612

Fornaguera C., Guerra-Rebollo M., Lázaro M.A., Cascante A., Rubio N., Blanco J., Borrós S., IN VIVO RETARGETING OF POLY (BETA AMINOESTER) (OM-PBAE) NANOPARTICLES IS INFLUENCED BY PROTEIN CORONA. Advanced Healthcare Materials 7(17) (2019) 1800335. DOI: 10.1002/adhm.201800335

Riera R., Feiner-Gracia N., Fornaguera C., Cascante A., Borrós S., Albertazzi L., TRACKING COMPLEXATION STATE OF PBAE POLYPLEXES IN CELLS WITH SUPER RESOLUTION MICROSCOPY. Nanoscale (2019). DOI: 10.1039/C9NR02858G

Brugada-Vilà P., Cascante A., Lázaro M.A., Castells-Sala C., Fornaguera C., Rovira-Rigau M., Albertazzi L., Borrós S., Fillat C., OLIGOPEPTIDE-MODIFIED POLY(BETA-AMINO ESTER)S-COATED ADNUPARME1A: BOOSTING THE EFFICACY OF INTRAVENOUSLY ADMINISTERED THERAPEUTIC ADENOVIRUSES. Theranostics, 2020; 10(6):2744-2758 doi:10.7150/thno.40902.

García-Fernández C., Fornaguera C.*, Borrós S., Nanomedicine in Non-Small Cell Lung Cancer: From Conventional Treatments to Immunotherapy. Cancers, 2020, 12(6), 1609. DOI: 10.3390/cancers12061609.

Salinas Y., Kneidinger M., Fornaguera C., Borrós S., Bruggemann O., Teasdale I., Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells. RSC Advances, 2020, 10(46), 27305-27314, DOI: 10.1039/D0RA03210G

García-Fernández C., Saz A., Fornaguera C.*, Borrós S., Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines, Cancer Gene Therapy, 1-12, 2021, DOI: 10.1038/s41417-021-00333-5

Giacobino C., Canta M., Fornaguera C., Borrós S., Cauda V., Extracellular vesicles and their current role in cancer immunotherapy, Cancers, 13(9), 2021. DOI: 10.3390/cancers13092280

Fornaguera C.*, Díaz-Caballero M., García-Fernandez C., Olmo L., Stampa-López Pinto M., Navalón-López M., Guerra-Rebollo M., Borrós S., Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes. JoVe, (2021). DOI: 10.3791/62889.

Guerra-Rebollo M., Stampa Lopez-Pinto M., Fornaguera C.*, Borrós S., Electrostatic coating of viral particles for gene delivery applications in muscular dystrophies: influence of size on stability and antibody protection. Accepted in Journal of Neuromuscular Diseases.

Marta Parés, Cristina Fornaguera, Ferran Vila-Julià, Sejin Oh, Steven H Y Fan, Ying K Tam, Natalia Comes, Francisco Vidal, Ramon Martí, Salvador Borrós, Jordi Barquinero, Preclinical Assessment of a Gene-Editing Approach in a Mouse Model of Mitochondrial Neurogastrointestinal Encephalomyopathy. Human Gene Therapy (2021). DOI: 10.1089/hum.2021.152

 

Grup d’Enginyeria de Materials IQS (Gemat)