• Dr. Antoni Planas Sauter

Dr. Antoni Planas
Laboratory of Biochemistry, Bioengineering Department
Biological Chemistry and Biotechnology Group (GQBB)
IQS School of Engineering
Universitat Ramon Llull
Via Augusta 390, 08017 Barcelona, Spain
Tel. +34 93 267 20 00
Fax +34 93 205 62 66

email: 
antoni.planas@iqs.url.edu

PhD in Chemical Engineering (IQS, 1987)
Degree in Chemical Engineering (IQS, 1982)
Degree in Biochemistry (UAB, 1987)
Postdoctoral fellow in Biochemistry and Molecular Biology (University of California, Berkeley, 1988-1989)
Research Associate (Universitat Autònoma de Barcelona, 1990-1992)
Professor at IQS since 1993. Visiting Professor:Univ. of California, Berkeley (1992)
University of Antioquia, Colombia (1997 and 2006)
INSA, Toulouse, France (2005)
Univ. of Connecticut, USA (2017-18).

 
Professor (2003-),
Head of the Bioengineering Department (2007-2018)
Head of the Biochemistry Laboratory (1993-)
Coordinator of the Biological Chemistry and Biotechnology Group (GQBB, 1999-)
President, Grupo Especializado de Hidratos de Carbono, Real Sociedad Española de Química (2021-)
Board member, Division of Chemistry in Life Sciences, European Chemical Society (EuChemS) (2020-)
Board member, European Carbohydrate Organization, Spanish representative (2015-)
President, European Carbohydrate Organization (2017-2019)
Elected academic fellow of the Reial Acadèmia de Cièncias i Arts de Barcelona (2019-)
Emyl Fischer Award 2013 by the European Carbohydrate Organization 

 

Subjects

Biochemistry (Degree in Chemistry)

Metabolism and Regulation, Protein Engineering, Interdisciplinary Seminars (Degree in Biotechnology)

Synthetic Biology (Master in Bioengineering)


Research Lines

Enzyme engineering in Glycobiology and Biocatalysis. Biomedical targets. Protein structure-function. Metabolic Engineering.

  • Protein engineering and enzymology of glycosidases, glycosyltranferases, and carbohydrate esterases
  • Therapeutic targets in infectious diseases
  • Biocatalysis: enzyme redesign, directed evolution of enzymes
  • Genetic and Metabolic Engineering of bacteria, yeast, and microalgae for the production of high-value products
  • Amyloidogenic proteins in neurodegenerative diseases.

Representative publications

Updated list of publications: https://scholar.google.com/citations?hl=en&user=cW3eqicAAAAJ

Recent publications: 

M. Castejón-Vilatersana, M. Faijes, A. Planas
Transglycosylation activity of engineered Bifidobacterium lacto-N-biosidase mutants at donor subsites for lacto-N-tetraose synthesis
International Journal of Molecular Sciences 22, 3230 (2021). https://doi.org/10.3390/ijms22063230. 

E.Y. Cotrina, L. Miguel Santos, J. Rivas, D. Blasi, J.P. Leite, M.A. Liz, M. A. Busquets, A. Planas, R. Prohens, A. Gimeno, J. Jiménez-Barbero, L. Gales, J. Llop, J. Quintana, I. Cardoso, G. Arsequell
Targeting transthyretin in Alzheimer’s disease: drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer’s disease
European Journal of Medicinal Chemistry 226, 113847 (2021). https://doi.org/10.1016/j.ejmech.2021.113847.

A.R. Pote, S. Pascual, A. Planas, M.W. Peczuh
Indolyl Septanoside Synthesis for In Vivo Screening of Bacterial Septanoside Hydrolases
International Journal of Molecular Sciences 22, 4497 (2021). https://doi.org/10.3390/ijms22094497.

S. Pascual, A Planas
Carbohydrate de-N-acetylases acting on structural polysaccharides and glycoconjugates
Current Opinion in Chemical Biology 61, 9–18 (2021). https://doi.org/10.1016/j.cbpa.2020.09.003.

C. Alsina, E. Sancho-Vaello, A. Aranda-Martínez, M. Faijes, A. Planas
Auxiliary active site mutations enhance the glycosynthase activity of a GH18 chitinase for polymerization of chitooligosaccharides.
Carbohydrate Polymers 252, 117121 (2021) https://doi.org/10.1016/j.carbpol.2020.117121

E.Y. Cotrina, M. Vilà, J. Nieto, G.Arsequell, A. Planas
Preparative Scale Production of Recombinant Human Transthyretin for Biophysical Studies of Protein-Ligand and Protein-Protein Interactions.
International Journal of Molecular Sciences  21, 9640  (2020). https://doi.org/10.3390/ijms21249640.

E.Y. Cotrina, D. Blasi, M. Vilà, A. Planas, C. Abad-Zapatero, N.B. Centeno, J. Quintana, G. Arsequell,
Optimization of Kinetic Stabilizers of Tetrameric Transthyretin: A Prospective Ligand Efficiency guided Approach.
Bioorganic and Medicinal Chemistry 28, 115794 (2020). http://doi.org/10.1016/j.bmc.2020.115794.

J. Chi, M. Cova, M. de las Rivas, A. Medina., R. Junqueira Borges, P. Leivar, A. Planas, I. Usón, R. Hurtado-Guerrero, L. Izquierdo.
Plasmodium falciparum apicomplexan-specific glucosamine-6-phosphate N-acetyltransferase is key for amino sugar metabolism and asexual blood stage development.
mBio 11:e02045-20 (2020) https://doi.org/10.1128/mBio.02045-20.

N. Orive-Milla, T. Demulle, M. de Mey, M. Faijes, A Planas
Metabolic engineering for glycoglycerolipids production in E. coli: tuning phosphatidic acid and UDP-glucose pathways
Metabolic Engineering 61, 106-119 (2020). https://doi.org/10.1016/j.ymben.2020.05.010.

L. Grifoll-Romero, M.A. Sainz-Polo, D. Albesa-Jové, M.E. Guerin, X. Biarnés, A. Planas
Structure-function relationships underlying the dual N-acetylmuramic and N-acetylglucosamine specificities of the peptidoglycan deacetylase PdaC from Bacillus subtilis.
Journal of Biological Chemistry 294, 19066-80 (2019). doi: 10.1074/jbc.RA119.009510.

C. Alsina, M. Faijes, A. Planas
Glycosynthase-type GH18 mutant chitinases at the assisting catalytic residue for polymerization of chitooligosaccharides
Carbohydrate Research 478, 1-9 (2019). Doi:10.1016/j.carres.2019.04.001.

M. Faijes, M. Castejón, C. Val-Cid, A. Planas
Enzymatic and cell factory approaches to the production of human milk oligosaccharides
Biotechnology Advances 37, 667–697 (2019). https://doi.org/10.1016/j.biotechadv.2019.03.014.

J. Romero-García, X. Biarnés, A. Planas
Essential mycoplasma glycolipid synthase adheres to the cell membrane by means of an amphipathic helix.
Scientific Reports 9, 7085 (2019). http://doi.org/10.1038/s41598-019-42970-9

S. Pascual, A. Planas
Screening assay for directed evolution of chitin deacetylases. application to Vibrio cholerae deacetylase mutant libraries for engineered specificity
Analytical Chemistry 90, 10654–10658 (2018). http://dx.doi.org/10.1021/acs.analchem.8b02729.

C Alsina, A. Aranda-Martínez, E. Sancho-Vaello, X. Biarnés, M. Faijes, A. Planas
Engineering GH18 chitinases for the production of sequence-defined chitosan polymers
Revista de la Societat Catalana de Química 17, 32-44 (2018).

L. Grifoll, S. Pascual, H. Aragunde, X. Biarnés, A. Planas
Chitin deacetylases: structures, specificities, and biotech applications
Polymers 10, 352 (2018). https://doi.org/10.3390/polym10040352.

H. Aragunde, X.Biarnés, A.Planas
Substrate recognition and specificity of chitin deacetylases and related family 4 carbohydrate esterases
International Journal of Molecular Sciences 19, 412 (2018). https://doi.org/10.3390/ijms19020412.

A. Aranda-Martinez, L. Grifoll-Romero, H.Aragunde, E. Sancho-Vaello, X. Biarnés, L. Vicente Lopez-Llorca, A. Planas
Expression and specificity of a chitin deacetylase from the nematophagous fungus Pochonia chlamydosporia potentially involved in pathogenicity
Scientific Reports 8, 2170 (2018). https://doi.org/10.1038/s41598-018-19902-0.

J. Coines, M. Alfonso-Prieto, X. Biarnés, A. Planas, C. Rovira
Oxazoline or oxazolinium ion? The protonation state and conformation of the reaction intermediate of chitinase enzymes revisited
Chemistry A European Journal 24, 19258-19265 (2018). doi: http://dx.doi.org/10.1002/chem.201803905.


Biological Chemistry and Biotechnology Group (GQBB)