Dr. Antoni Planas Sauter


Antoni Planas

Dr. Antoni Planas

Laboratory of Biochemistry, Bioengineering Department
Biological Chemistry and Biotechnology Group (GQBB)
IQS School of Engineering
Universitat Ramon Llull
Via Augusta 390, 08017 Barcelona, Spain
Tel. +34 93 267 20 00
Fax +34 93 205 62 66

email: 
antoni.planas@iqs.url.edu

PhD in Chemical Engineering (IQS, 1987), Degree in Chemical Engineering (IQS, 1982), Degree in Biochemistry (UAB, 1987). Postdoctoral fellow in Biochemistry and Molecular Biology (University of California, Berkeley, 1988-1989), Research Associate (Universitat Autònoma de Barcelona, 1990-1992). Professor at IQS since 1993. Visiting Professor:Univ. of California, Berkeley (1992), University of Antioquia, Colombia (1997 and 2006), INSA, Toulouse, France (2005), Univ. of Connecticut, USA (2017-18).

 

Professor (2003-),

Head of the Bioengineering Department (2007-)

Head of the Biochemistry Laboratory (1993-)

Coordinator of the Biological Chemistry and Biotechnology Group (GQBB, 1999-)

 

Subjects

Biochemistry (Degree in Chemistry)

Metabolism and Regulation, Protein Engineering, Interdisciplinary Seminars (Degree in Biotechnology)

Synthetic Biology (Master in Bioengineering)


Research Lines

Enzyme engineering in Glycobiology and Biocatalysis. Biomedical targets. Protein structure-function. Metabolic Engineering.

  • Protein engineering and enzymology of glycosidases, glycosyltranferases, and carbohydrate esterases
  • Therapeutic targets in infectious diseases
  • Biocatalysis: enzyme redesign, directed evolution of enzymes
  • Genetic and Metabolic Engineering of bacteria, yeast, and microalgae for the production of high-value products
  • Amyloidogenic proteins in neurodegenerative diseases.

Representative publications

Updated list of publications: https://scholar.google.com/citations?hl=en&user=cW3eqicAAAAJ

   http://www.researcherid.com/rid/I-4803-2015

 

- D. Albesa-Jové, J. Romero-García, E. Sancho-Vaello, F.X. Contreras, A. Rodrigo-Unzueta, N. Comino, A. Carreras-González, P. Arrasate, S. Urresti, X. Biarnés, A. Planas, M.E. Guerin. Structural Snapshots and Loop Dynamics Along the Catalytic Cycle of Glycosyltransferase GpgS. Structure 25, 1034-1044 (2017). http://dx.doi.org/10.1016/j.str.2017.05.009

 

- J. Durand, X..Biarnés, L. Watterlot, C. Bonzom, V. Borsenberger, A. Planas, S. Bozonnet, M.J. O’Donohue, R. Fauré. A single point mutation alters the hydrolysis/transglycosylation partition, significantly enhancing the synthetic capability of an endo-glycoceramidase. ACS Catalysis 6, 8264–8275 (2016). http://pubs.acs.org/doi/abs/10.1021/acscatal.6b02159

 

- V. Codera, K.J. Edgar, M. Faijes, A. Planas. Functionalized celluloses with regular substitution pattern by glycosynthase-catalyzed polymerization. Biomacromolecules, 17(4),1272-9 (2016).

http://pubs.acs.org/doi/10.1021/acs.biomac.5b01453

 

- B. Bissaro, J. Durand, X.Biarnés., A. Planas, P. Monsan, R. Fauré, M. J. O'Donohue. Molecular Design of Non-Leloir Furanose-Transferring Enzymes from an α-L-Arabinofuranosidase: A Rationale for the Engineering of Evolved Transglycosylases. ACS Catalysis 5, 4598-4611 (2015),

      http://pubs.acs.org/doi/abs/10.1021/acscatal.5b00949

 

- D. Albesa-Jové, M.F. Mendoza, A. Rodrigo-Unzueta, F. GomollónBel, J. Cifuente, S. Urresti, N. Comino, H. Gómez, J.Romero-García, J.M. Lluch, E. Sancho-Vaello, X. Biarnés, A. Planas, P. Merino, L. Masgrau, M.E. Guerin. A natural ternary complex trapped in crystal reveals the catalytic mechanism of a retaining glycosyltransferase. Angewandte Chemie Int. Ed. 54, 9898-9902 (2015).

http://onlinelibrary.wiley.com/doi/10.1002/anie.201504617/abstract

 

- E. Andrés, D. Albesa-Jové, X. Biarnés, B. M. Moerschbacher, M. E. Guerin, A. Planas.

Structural basis of chitin oligosaccharide deacetylation. Angewandte Chemie Int. Ed. 53, 6882–6887 (2014).

http://onlinelibrary.wiley.com/doi/10.1002/anie.201400220/abstract

 

- V. Codera, H. J. Gilbert, M. Faijes, A.Planas. Carbohydrate Binding Module assisting glycosynthase-catalyzed polymerizations. Biochemical Journal, 470, 15-22 (2015).

http://www.biochemj.org/content/470/1/15

 

- E. Andrés; H. Aragunde; A.Planas. Screening glycosynthase libraries with a fluoride chemosensor assay independent of enzyme specificity. Identification of a transitional hydrolase to synthase mutant. Biochem. J. 458, 355-363 (2014).

http://www.biochemj.org/content/458/2/355

 

     - G.J. Davies; A. Planas; C. Rovira. Conformational analyses of the reaction coordinate of glycosidases

Accounts of Chemical Research 45, 308-316 (2012).

http://pubs.acs.org/doi/abs/10.1021/ar2001765

 

- Mora-Buyé, N.; Faijes, M.; Planas, A. An engineered E. coli strain for the production of glycoglycerolipids. Metabolic Eng., 14, 551-559 (2012).

http://www.sciencedirect.com/science/article/pii/S1096717612000663?via%3Dihub

 

- X. Pérez, M. Faijes, A. Planas. Artificial mixed-linked beta-glucans produced by glycosynthase-catalyzed polymerization: tuning morphology and degree of polymerization. Biomacromolecules,12, 494-501 (2011).

http://pubs.acs.org/doi/abs/10.1021/bm1013537

 

- Biarnés X, Ardèvol A, Iglesias-Fernández J, Planas A, Rovira C. Catalytic Itinerary in 1,3-1,4-beta-Glucanase Unraveled by QM/MM Metadynamics. Charge Is Not Yet Fully Developed at the Oxocarbenium Ion-like Transition State. J. Am. Chem. Soc. 133, 20301-20309 (2011).

http://pubs.acs.org/doi/abs/10.1021/ja207113e

 

- E. Andrés; N. Martínez; A. Planas. Expression and characterization of a Mycoplasma genitalium glycosyltransferase in membrane glycolipid biosynthesis. Potential target against mycoplasma infections.

J. Biol. Chem. 286, 35367-35379 (2011).

http://www.jbc.org/content/286/41/35367.abstract

 

     - A. Planas, M. Faijes, V. Codera. When enzymes do it better: enzymatic glycosylation methods

In Carbohydrates Chemistry: State-of-the-art and challenges for drug development (L. Cipolla, Ed.), Imperial College Press, London, July 2015, ISBN: 9781783267194

 


Research groups

Biological Chemistry and Biotechnology Group (GQBB)