• Dr. Carlos E. Semino

Dr. Carlos E. Semino

Tissue Engineering Laboratory, Bioengineering Department

ICREC Group: Cardiac Insufficiency and Cardiac Regeneration
IQS School of Engineering
Universitat Ramon Llull
Via Augusta 390, E-08017 Barcelona, Spain
Tel. +34 932 672 000 x407
Fax +34 932 056 266

Center for Biomedical Engineering,
Massachusetts Institute of Technology (MIT)
77 Massachusetts Avenue, Building NE47
Cambridge, MA 02139

Translationszentrum für Regenerative Medizin (TRM), Universität Leipzig
Semmelweisstraße 14, 04103 Leipzig, Germany
Tel. (0341) 97 39661


Education: PhD in Chemistry (1994, University of Buenos Aires, Argentina), Master in Science in Genetics and Molecular Biology (1990, University of Buenos Aires, Argentina).

Academic positions: Associate Professor, Assistant Professor (2007-), Head of the Tissue Engineering Laboratory at IQS-Barcelona, Visiting Professor at the Translationszentrum für Regenerative Medizin (TRM-Leipzig), Germany.


Molecular Biology, Cell Cultures and Tissue Engineering.


Research Lines

-Culture, maintenance and differentiation of adult and embryonic stem cells
-Development of bioengineering platforms to recreate cellular microenvironments
-In vitro models for normal and malignant skeletal and organ systems
-Development of biomedical platforms for cellular therapy


Representative Publications

Heparin based self-assembling peptide scaffold reestablish chondrogenic phenotype of expanded de-differentiated human chondrocytes.Recha-Sancho L, Semino CE. J Biomed Mater Res A. 2016 Mar 3. [Epub ahead of print]


Three-Dimensional Cultures of Human Subcutaneous Adipose Tissue-Derived Progenitor Cells Based on RAD16-I Self-Assembling Peptide.Castells-Sala C, Recha-Sancho L, Llucià-Valldeperas A, Soler-Botija C, Bayes-Genis A, Semino CE. Tissue Eng Part C Methods. 2016 Jan 7. [Epub ahead of print]


Chondrogenic potential of human dermal fibroblasts in a contractile, soft, self-assembling, peptide hydrogel.
Bussmann BM, Reiche S, Marí-Buyé N, Castells-Sala C, Meisel HJ, Semino CE. J Tissue Eng Regen Med. 2016 Feb;10(2):E54-62


Cardiac differentiation potential of human induced pluripotent stem cells in a 3D self-assembling peptide scaffold.Puig-Sanvicens VA, Semino CE, Zur Nieden NI. Differentiation. 2015 Nov-Dec;90(4-5):101-10


in vitro development of bioimplants made up of elastomeric scaffolds with peptide gel filling seeded with human subcutaneous adipose tissue-derived progenitor cells.Castells-Sala C, Martínez-Ramos C, Vallés-Lluch A, Monleón Pradas M, Semino C. J Biomed Mater Res A. 2015 Nov;103(11):3419-30.


Effective and durable genetic modification of human mesenchymal stem cells via controlled release of rAAV vectors from self-assembling peptide hydrogels with a maintained differentiation potency.Rey-Rico A, Venkatesan JK, Frisch J, Schmitt G, Monge-Marcet A, Lopez-Chicon P, Mata A, Semino C, Madry H, Cucchiarini M. Acta Biomater. 2015 May;18:118-27.


Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications.Fernández-Muiños T, Recha-Sancho L, López-Chicón P, Castells-Sala C, Mata A, Semino CE.
Acta Biomater. 2015 Jan 13. pii: S1742-7061(15)00009-4.


Bioengineering 3D environments for cancer models.Alemany-Ribes M, Semino CE. Adv Drug Deliv Rev. 2014 Dec 15;79-80:40-9.


Multivalent dendrimers presenting spatially controlled clusters of binding epitopes in thermoresponsive hyaluronan hydrogels.
Seelbach RJ, Fransen P, Peroglio M, Pulido D, Lopez-Chicon P, Duttenhoefer F, Sauerbier S, Freiman T, Niemeyer P, Semino C, Albericio F, Alini M, Royo M, Mata A, Eglin D. Acta Biomater. 2014 Oct;10(10):4340-50.


Engineered 3D bioimplants using elastomeric scaffold, self-assembling peptide hydrogel, and adipose tissue-derived progenitor cells for cardiac regeneration.Soler-Botija C, Bagó JR, Llucià-Valldeperas A, Vallés-Lluch A, Castells-Sala C, Martínez-Ramos C, Fernández-Muiños T, Chachques JC, Pradas MM, Semino CE, Bayes-Genis A. Am J Transl Res. 2014 May 15;6(3):291-301. eCollection 2014.


Online monitoring of myocardial bioprosthesis for cardiac repair.
Prat-Vidal C, Gálvez-Montón C, Puig-Sanvicens V, Sanchez B, Díaz-Güemes I, Bogónez-Franco P, Perea-Gil I, Casas-Solà A, Roura S, Llucià-Valldeperas A, Soler-Botija C, Sánchez-Margallo FM, Semino CE, Bragos R, Bayes-Genis A. Int J Cardiol. 2014 Jul 1;174(3):654-61.


Matrix dimensions, stiffness, and structural properties modulate spontaneous chondrogenic commitment of mouse embryonic fibroblasts.Fernández-Muiños T, Suárez-Muñoz M, Sanmartí-Espinal M, Semino CE. Tissue Eng Part A. 2014 Apr;20(7-8):1145-55.


Creating the bioartificial myocardium for cardiac repair: challenges and clinical targets.Chachques JC, Pradas MM, Bayes-Genis A, Semino C. Expert Rev Cardiovasc Ther. 2013 Dec;11(12):1701-11. Review.


Tissue engineering for articular cartilage repair--the state of the art.
Johnstone B, Alini M, Cucchiarini M, Dodge GR, Eglin D, Guilak F, Madry H, Mata A, Mauck RL, Semino CE, Stoddart MJ.
Eur Cell Mater. 2013 May 2;25:248-67. Review.


Toward a 3D cellular model for studying in vitro the outcome of photodynamic treatments: accounting for the effects of tissue complexity.Alemany-Ribes M, García-Díaz M, Busom M, Nonell S, Semino CE. Tissue Eng Part A. 2013 Aug;19(15-16):1665-74.


Development of a three-dimensional bone-like construct in a soft self-assembling peptide matrix.Marí-Buyé N, Luque T, Navajas D, Semino CE. Tissue Eng Part A. 2013 Apr;19(7-8):870-81.


Influence of electrical stimulation on 3D-cultures of adipose tissue derived progenitor cells (ATDPCs) behavior.
Castells-Sala C, Sanchez B, Recha-Sancho L, Puig V, Bragos R, Semino CE. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5658-61.


Biomaterials for stem cell culture and seeding for the generation and delivery of cardiac myocytes.Castells-Sala C, Semino CE.
Curr Opin Organ Transplant. 2012 Dec;17(6):681-7.


Differentiation of mouse embryonic stem cells in self-assembling peptide scaffolds.Marí-Buyé N, Semino CE. Methods Mol Biol. 2011;690:217-37.


Nanometric self-assembling peptide layers maintain adult hepatocyte phenotype in sandwich cultures. Wu J, Marí-Buyé N, Muiños TF, Borrós S, Favia P, Semino CE. J Nanobiotechnology. 2010 Dec 12;8:29.


Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro.Genové E, Schmitmeier S, Sala A, Borrós S, Bader A, Griffith LG, Semino CE. J Cell Mol Med. 2009 Sep;13(9B):3387-97. 


Research Groups

The Group of Pharmaceutical Chemistry