Dr. Carlos E. Semino

Subjects

Molecular Biology: 2nd course in Degree in Biotechnology
Cell Culture: 3rd course Degree in Biotechnology
Tissue Engineering: 4th course Degree in Biotechnology
Advances in Tissue Engineering: Master in Bioengineering
Evaluation of Compounds with Biological Activity: Master in Pharmaceutical Chemistry
Toxicology Laboratory: 4th course Degree in Farmacy
Tissue Culture Laboratory: Master in Bioengineering
Tissue Culture Laboratory: Master in Pharmaceutical Chemistry

Research Lines

• Culture, maintenance and differentiation of adult and embryonic stem cells
• Development of bioengineering platforms to recreate cellular microenvironments
• In vitro models for normal and malignant skeletal and organ systems
• Development of biomedical platforms for cellular therapy

Representative Publications

Book:

THE NEVER_ENDING STORY OF LIFE. A brief journey through concepts of biology. Carlos E. Semino. Springer-Nature 2021. ISBN: 978-3-030-75968-1.

Scientific Journals:
Betriu, N.; Bertran-Mas, J.; Andreeva, A.; Semino, C. E., Syndecans and Pancreatic Ductal Adenocarcinoma. Biomolecules 2021, 11 (3).

Betriu, N.; Andreeva, A.; Semino, C. E., Erlotinib Promotes Ligand-Induced EGFR Degradation in 3D but Not 2D Cultures of Pancreatic Ductal Adenocarcinoma Cells. Cancers 2021, 13 (18).

Sennett, M et al,. Long term outcomes of biomaterial-mediated repair of focal Cartilage defests in a Large animal mode. European Cells and materials 2021, 41: 40-51.

N Betriu, C Jarrosson-Moral, CE Semino. Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold. Biomolecules, 2020 Apr 28;10(5): E684.

Chachques JC, Lila N, Soler-Botija C, Martinez-Ramos C, Valles A, Autret G, Perier MC, Mirochnik N, Monleon-Pradas M, Bayes-Genis A, Semino. CE. Elastomeric cardiopatch scaffold for myocardial repair and ventricular support. Eur J Cardiothorac Surg. 2020 Mar 1;57(3):545-555.

Rubí-Sans G, Recha-Sancho L, Pérez-Amodio S, Mateos-Timoneda MÁ, Semino CE, Engel E. Development of a Three-Dimensional Bioengineered Platform for Articular Cartilage Regeneration. Biomolecules. 2019 Dec 28;10(1):52

C Cofiño, S Perez‐Amodio, CE Semino, E Engel, MA Mateos‐Timoneda. Development of a Self‐Assembled Peptide/Methylcellulose‐Based Bioink for 3D Bioprinting. Macromolecular Materials and Engineering. 2019 (accepted).

Betriu N, Semino CE. Development of a 3D Co-Culture System as a Cancer Model Using a Self-Assembling Peptide Scaffold. Gels. 2018 Aug 2;4(3). pii: E65. doi: 10.3390/gels4030065.

Betriu N, Recha-Sancho L, Semino CE. Culturing mammalian Cells in Three-dimensional Peptide Scaffolds. J Vis Exp. 2018 Jun 13;(136). doi: 10.3791/57259.

Moreno-Amador JL, Téllez N, Marin S, Aloy-Reverté C, Semino C, Nacher M, Montanya E. Epithelial to mesenchymal transition in human endocrine islet cells.   PLoS One. 2018 Jan 23;13(1):e0191104. 2018.

Aloy-Reverté C, Moreno-Amador JL, Nacher M, Montanya E, Semino CE. Use of RGD-Functionalized Sandwich Cultures to Promote Redifferentiation of Human Pancreatic Beta Cells After In Vitro Expansion. Tissue Eng Part A. Aug 31. doi: 10.1089/ten.tea.2016.0493. [Epub ahead of print]. 2017

I González-Valverde, C Semino, JM García-Aznar. Phenomenological modelling and simulation of cell clusters in 3D cultures. Computers in Biology and Medicine 77, 249-260. 2016

L Recha-Sancho, FT Moutos, J Abellà, F Guilak, CE Semino. Dedifferentiated Human Articular Chondrocytes Redifferentiate to a Cartilage-Like Tissue Phenotype in a Poly (ε-Caprolactone)/Self-Assembling Peptide Composite Scaffold. Materials 9 (6), 472 (2016)

JC Chachques, Juan Carlos, A Bayes Genis, N Lila, C Soler, N Mirochnik, G Autret, C Semino. Development of bioartificial myocardium and ventricular support bioprostheses using nanobiotechnologies. EUROPEAN JOURNAL OF HEART FAILURE (18): 459-459. 2016

Recha-Sancho L, Semino CE. Chondroitin Sulfate and Decorin based self-assembling scaffolds for cartilage tissue engineering. PlosOne11 (6), e0157603. 2016

Recha-Sancho L, Semino CE. Heparin based self-assembling peptide scaffold reestablish chondrogenic phenotype of expanded de-differentiated human chondrocytes. J Biomed Mater Res A. 2016 104 (7), 1694-1706

Castells-Sala C, Recha-Sancho L, Llucià-Valldeperas A, Soler-Botija C, Bayes-Genis A, Semino CE. Three-Dimensional Cultures of Human Subcutaneous Adipose Tissue-Derived Progenitor Cells Based on RAD16-I Self-Assembling Peptide. Tissue Eng Part C Methods 22 (2), 113-124. 2016

research group

Group of Pharmaceutical Chemistry