• Dr. Santi Nonell Marrugat, FRSC

Dr. Santi Nonell Marrugat, FRSC
Applied Photobiological Chemistry
IQS School of Engineering
Universidad Ramon Llull
Via Augusta, 390
E-08017 Barcelona (España)
Tel:(+34) 93 267 2000
Fax: (+34) 93 205 6266


Ph.D. in Chemical Engineering (1988, IQS/Max-Planck Institut für Strahlenchemie), Degree in Chemical Sciences (1990, University of Barcelona), Degree in Chemical Engineering (1985, IQS)
Postdoctoral associate (Arizona State University / University of California Los Angeles, 1991-1992).

Professor (IQS, 1994-)
Head of the Biological Photochemistry Laboratory
Coordinator of the PhD in Chemistry and Chemical Engineering programme  (2013-)
President of the European Society for Photobiology (2017-2019) 
Director of the Photobiology School, European Society for Photobiology (2019-)
Editor-in-Chief of the journal Photochemical & Photobiological Sciences (2015-2017)
Fellow of the Royal Society of Chemistry
Otto Hahn Medal Award of the Max-Planck Society



Professor of Physical Chemistry, Molecular Physical Chemistry (taught in English), Frontiers in Chemistry (taught in English) and Photochemistry (taught in English)


Research Lines

  • Biological Photochemistry
  • Photodynamic therapy and theranostic Applications of light
  • Photofunctional molecules, proteins and nanostructured materials
  • Photoprotective sunscreens



Author of more than 200 scientific publications including 5 books and 13 book chapters. 

ResearcherID: L-2561-2013 
ORCID: 0000-0002-8900-5291

Soriano, J.;Pérez-Sánchez, A.; Ramírez-Barroso, S.; Illescas, B. M.; Azmani, K.; Rodríguez-Fortea, A.; Poblet, J. M.; Hally, C.; Nonell, S.; García-Fresnadillo, D.; Rojo, J.; Martín, N. Ultra long-lived triplet excited state in water at room temperature: Insights on the molecular design of tridecafullerenes. Angew. Chem. Int. Ed. 2021, 60(29), 16109-16118

Bresolí-Obach, Roger; Massad, Walter; Abudulimu, Abasi; Lüer, Larry; Flors, Cristina; Gutierrez-Luis, Javier; Rosquete, Laura; Abad-Grillo, Teresa; Anamimoghadam, Ommid; Buecher, Goetz; Nonell, Santi. 9-Aryl-phenalenones: bioinspired thermally reversible photo-chromic compounds for photoswitching applications in the pico- to milliseconds range. Dyes Pigm. 2021, 186, 109060

de las Heras, E.; Boix-Garriga, E.; Bryden, F.; Agut, M.; Mora, M.; Sagristá, M. L.; Boyle, R. W.; Lange, N.; Nonell, S. c(RGDfK)- and ZnTriMPyP-bound polymeric nanocarriers for tumor-targeted photodynamic therapy. Photochem. Photobiol. 2020, 96, 570–580

Nieves, I.; Hally, C.; Viappiani, C.; Agut, M.; Nonell, S. A porphycene-gentamicin conjugate for enhanced photodynamic inactivation of bacteria, Bioorg. Chem. 2020, 97, 103661. 

Torra, J.; Lafaye, C.; Signor, L.; Aumonier, S.; Flors, C.; Shu, X.; Nonell, S.; Gotthard, G.; Royant, A. Tailing miniSOG: Structural bases of the complex photophysics of a flavin-binding singlet oxygen photosensitizing protein. Sci. Rep. 2019, 9, 2428

Hally, C.; Rodríguez-Amigo, B.; Bresolí-Obach, R.; Planas, O.; Nos, J.; Boix-Garriga, E.; Ruiz-González, R.; Nonell, S., “Photodynamic Therapy”, in Theranostics and Image Guided Drug Delivery, edited by Maya Thanou, The Royal Society of Chemistry, London, 2018, 86-122.

Ruiz-González, R.; Bresolí-Obach, R.; Gulías, O.; Agut, M.; Savoie, H.; Boyle, R. W.; Nonell, S.; Giuntini, F. NanoSOSG: a nanostructured fluorescent probe for the detection of intracellular singlet oxygen, Angew. Chem. Int. Ed. 2017, 56(11), 2885-2888

Ruiz-González, R.; Milán, P.; Bresolí-Obach, R.; Stockert, J.C.; Villanueva, A.; Cañete, M.; Nonell, S. Photodynamic synergistic effect of pheophorbide a and doxorubicin in combined treatment against tumoral cells, Cancers, 2017, 9, 18

Wainwright, M.; Maisch, T.; Nonell, S.; Plaetzer, K.; Almeida, A.; Tegos, G. P.; Hamblin, M. R. Photoantimicrobials - Are we afraid of the light? Lancet Infect. Dis. 2017, 17(2), e49–e55

Planas, O.; Macia, N.; Agut, M.; Nonell, S.; Heyne, B. Distance-dependent plasmon-enhanced singlet oxygen production and emission for bacterial inactivation. J. Am. Chem. Soc. 2016, 138(8), 2762-2768

Nonell S., Flors. C. (editors), Singlet Oxygen. Applications in Biosciences and Nanosciences, The Royal Society of Chemistry, London, 2016

Planas, O.; Gallavardin, T.; Nonell, S. A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents, Chem Commun. 2015, 51, 5586-5589

Ruiz-González, R.; Cortajarena, A.L.; Mejias, S.H.; Agut, M.; Nonell, S.; Flors, C., Singlet oxygen generation by the genetically-encoded tag miniSOG. J. Am. Chem. Soc. 2013, 135(26), 9564-9567

Ragàs, X.; Sánchez-García, D.; Ruiz-González, R.; Dai, T.; Agut, M.; Hamblin, M.R.; Nonell, S. Cationic porphycenes as potential photosensitizers for antimicrobial photodynamic therapy, J. Med. Chem., 2010, 53 (21), 7796–7803

Ragàs, X.; Agut, M.; Nonell, S. Singlet oxygen in E. coli: new insights for antimicrobial photodynamic therapy, Free Radical Biol. Med. 2010, 49, 770–776

Ragàs X.; Jiménez-Banzo, A.; Sánchez-García, D., Batllori, X., Nonell, S. Singlet oxygen photosensitisation by the fluorescent probe Singlet Oxygen Sensor Green, Chem. Commun. 2009, 20, 2920-2922

Flors, C.; Nonell, S., Light and singlet oxygen in plant defense against pathogens: phototoxic phenalenone phytoalexins, Acc. Chem. Res., 2006, 39 (5), 293-300


Research Groups

Applied Photobiological Chemistry