• Dr. Santi Nonell Marrugat, FRSC

Dr. Santi Nonell Marrugat, FRSC

Applied Photobiological Chemistry

IQS School of Engineering
Universidad Ramon Llull
Via Augusta, 390
E-08017 Barcelona (España)
Tel:(+34) 93 267 2000
Fax: (+34) 93 205 6266


Ph.D. in Chemical Engineering (1988, IQS/Max-Planck Institut für Strahlenchemie), Degree in Chemical Sciences (1990, University of Barcelona), Degree in Chemical Engineering (1985, IQS)
Postdoctoral associate (Arizona State University / University of California Los Angeles, 1991-1992).
Professor (IQS, 1994-)
Head of the Photochemistry Laboratory
Fellow of the Royal Society of Chemistry
Otto Hahn Medal Award of the Max-Planck Society


Professor of Physical Chemistry, Molecular Physical Chemistry (taught in English), Frontiers in Chemistry (taught in English) y Photochemistry (taught in English)


Research Lines

  • Biological Photochemistry
  • Photodynamic therapy and theranostic Applications of light
  • Photofunctional molecules, proteins and nanostructured materials
  • Photoprotective sunscreens



Author of more than 140 papers in peer-reviewed journals and book chapters  
Editor of the journal Photochemical & Photobiological Sciences
Planas, O.; Gallavardin, T.; Nonell, S. A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents, Chem Commun. 2015,. DOI: http://dx.doi.org/10.1039/C4CC09070E.
Torra, J.; Burgos-Caminal, A.; Endres, S.; Wingen, M.; Drepper, T.; Gensch, T.; Ruiz-Gonzalez, R.; Nonell, S. Singlet oxygen photosensitisation by the fluorescent protein Pp2FbFP L30M, a novel derivative of Pseudomonas putida flavin-binding Pp2FbFP. Photochem. Photobiol. Sci. 2015, 14, 280-287.
Gallardo, A.; Morales J.; Comas-Barceló, J.; Gallavardin, T.; Acedo, P.; Villanueva A.; Nonell, S. “Silica-based nanostructured materials for biomedical applications”, in Applications of Nanoscience to Photomedicine (M.R. Hamblin and P. Avci, Eds.) Chandos Publishing, 2015, pp 425-444.
Rodríguez-Amigo, B.; Delcanale, P.; Rotger, G.; Juárez-Jiménez, J.; Abbruzzetti, S.; Summer, A.; Agut, M.; Luque, F.J.; Nonell, S.; Viappiani, C. The complex of hypericin with b-lactoglobulin has antimicrobial activity with perspective applications in dairy industry, J. Dairy Sci. 2015, 98(1), 89–94. 
Planas, O.; Boix-Garriga, E.; Rodríguez-Amigo, B.; Torra, J.; Bresolí-Obach, R.; Flors, C.; Viappiani, C.; Agut, M.; Ruiz-González, R.; Nonell, S. “Newest approaches to singlet oxygen photosensitisation in biological media", in Photochemistry: Volume 42, (A. Albini and E. Fasani, Eds.) 2015, 42, 233-278.
Bucher, G.; Bresolí-Obach, R.; Brosa, C.; Flors, C.; Luis, J.G.; Grillo, T.A.; Nonell, S. ?-Phenyl quenching of 9-phenylphenalenone. A novel photocyclisation reaction with biological implications. Phys. Chem. Chem. Phys, 2014, 16 (35), 18813-18820.
Dosselli, R.; Ruiz-González, R.; Agnolon, V.; Compagnin, C.; Moret, F.; Mognato, M.; Sella, V.; Agut, M.; Nonell, S.; Gobbo, M.; Reddi, E. Synthesis, spectroscopic, and photophysical characterization and photosensitizing activity toward prokaryotic and eukaryotic cells of porphyrin-magainin and –buforin conjugates. J. Med. Chem. 2014, 57, 1403?1415.
Ruiz-González, R.; Zanocco, R.; Gidi, Y.; Zanocco, A.L.; Nonell, S.; Lemp, E. Naphthoxazole-based singlet oxygen fluorescent probes. Photochem. Photobiol. 2013, 89, 1427–1432
Flors, C.; Nonell, S. “Genetically-encoded photosensitizers: structure, photosensitization mechanisms and potential application to photodynamic therapy”, in Handbook of Photomedicine (M.R. Hamblin and Y. Huang, Eds.) 2013, pp 275-280.
Comas-Barceló, J.; Rodríguez-Amigo, B.; Abbruzzetti, S.; del Rey-Puech, P.; Agut, M.; Nonell, S.; Viappiani, C. A self-assembled nanostructured material with photosensitising properties. RSC Adv. 2013, 3 (39), 17874 - 17879.
Rosas, E.; Santomá, P.; Hernandez, B.; Duran-Frigola, M.; Ruiz-González, R.; Llinas, M.C.; Sánchez-García, D.; Nonell, S.; Edelman, E.R.; Balcells, M. Modifications of microvascular EC surface modulate phototoxicity of a porphycene anti-ICAM-1 immunoconjugate; therapeutic implications. Langmuir 2013, 29(31), 9734-9743.
Alemany-Ribes, M.; Garcia-Diaz, M.; Busom, M.; Nonell, S.; Semino, C.E. Toward a 3D cellular model for studying in vitro the outcome of photodynamic treatments: Accounting for the effects of tissue complexity. Tissue Eng. Part A. 2013, 19(15-16), 1665-1674
Ruiz-González, R.; Cortajarena, A.L.; Mejias, S.H.; Agut, M.; Nonell, S.; Flors, C., Singlet oxygen generation by the genetically-encoded tag miniSOG. J. Am. Chem. Soc. 2013, 135(26), 9564-9567.
Nonell, S.; García-Díaz, M.; Viladot, J.L.; Delgado, R. Singlet molecular oxygen quenching by the antioxidant dimethylmethoxy chromanol in solution and in ex vivo porcine skin. Int. J. Cosmetic Sci. 2013, 35(3), 272–280.
Garcia-Amorós, J.; Díaz-Lobo, M.; Nonell, S.; Velasco, D. Fastest thermally-isomerised azobenzene for nanosecond photo-switching applications under physiological conditions, Angew. Chem. Int. Ed. 2012, 51(51), 12820-12823.
García-Díaz, M.; Kawakubo, M.; Mroz, P.; Sagristà, M.L.; Mora, M.; Nonell, S.; Hamblin, M.R. Cellular and vascular effects of the photodynamic agent temocene are modulated by the delivery vehicle. J. Control. Rel., 2012, 162, 355-363.
Ruiz-González R.; White, J.H.; Agut, M.; Nonell S.; Flors, C. A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen. Photochem. Photobiol. Sci., 2012, 11(9), 1411-1413.
López-Chicón, P.; Paz-Cristobal, M.P.; Rezusta, A.; Aspiroz, C.; Royo-Cañas, D.; Andres-Ciriano, E.; Gilaberte, Y.; Agut, M.; Nonell, S. On the mechanism of Candida spp. photoinactivation by hypericin, Photochem. Photobiol. Sci. 2012, 11, 1099-1107.
Ragàs, X.; Gallardo, A.; Zhang, Y.; Massad, M.; Geddes, C.D.; Nonell, S. Singlet oxygen phosphorescence enhancement by silver islands films, J. Phys. Chem. C, 2011, 115, 16275–16281.
Ragàs, X.; Cooper, L.P.; White, J.H.; Nonell, S.; Flors, C., Quantification of Photosensitized Singlet Oxygen Production by a Fluorescent Protein, ChemPhysChem. 2011, 12(1), 161-165. Cover of the January 2011 issue.
Ragàs, X.; Agut, M.; Nonell, S. Singlet oxygen in E. coli: new insights for antimicrobial photodynamic therapy, Free Radical Biol. Med. 2010, 49, 770–776.
Gallardo, A; Teixidó, J.; Miralles, R.; Raga, M.; Guglietta, A.; Marquillas, F.; Sallarès, J.; Nonell, S. Dose-dependent progressive sunscreens. A new strategy for photoprotection? Photochem. Photobiol. Sci., 2010, 9(4), 530-534.
Flors, C.; Nonell, S., Light and singlet oxygen in plant defense against pathogens: phototoxic phenalenone phytoalexins, Acc. Chem. Res., 2006, 39 (5), 293-300.


Research Groups

Applied Photobiological Chemistry